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Jun 29, 2016 Alzheimer's disease status in a large case–control dataset, particularly in connection with the APOEε4 allele. To de- termine if the effect of E318G on AD risk was different for APOEε4 homozygotes versus heterozygotes we calcu- using only APOEε3 homozygotes in the Cache County. Hippen et al. BMC Genomics 2016, 17(Suppl 3):438 All authors read and approved the final.